Role of molecular imaging in the detection of neuroendocrine tumour

نویسنده

  • Damian Wild
چکیده

Neuroendocrine tumours (NETs) have distinct biological and clinical characteristics, in particular a high density of somatostatin receptors at the cell membrane [1]. It is this property that allows the use of radiolabelled somatostatin analogues for imaging of these tumours. Importantly, somatostatin receptor PET/CT imaging (e.g. Ga-DOTATOC, Ga-DOTATATE, Ga-DOTANOC) is superior to somatostatin receptor scintigraphy including SPECT/CT [2] and F-DOPA PET/CT [3] in the detection of gastroenteropancreatic neuroendocrine tumours (GEP NETs). NETs, however, have a wide range of cellular differentiation. F-FDG PET/CT is of limited value in welldifferentiated NETs but of high value in poorly differentiated NETs. Somatostatin receptor PET/CT shows contrary results [4]. As both F-FDG PET/CT and somatostatin receptor PET/CT exploit distinct tumour characteristics they are complementary for tumour staging. Small insulinomas are difficult to detect with F-FDG PET/CT, somatostatin receptor PET/CT, F-DOPA PET/ CT and morphological imaging. Targeting of Glucagonlike peptide-1 receptors using radiolabelled exendin-4 has shown to be highly effective in the detection of these tumours [5]. Clinical studies have shown higher tumour uptake of radiolabelled somatostatin receptor antagonists than somatostatin receptor agonists [6]. As a result radiolabelled somatostatin receptor antagonists may have a significant impact on imaging of NETs. Published: 9 October 2014

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In vitro Study of SPIONs-C595 as Molecular Imaging Probe for Specific Breast Cancer (MCF-7) Cells Detection

Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanopartic...

متن کامل

Comparing PET metabolic parameters with clinicopathological factors in predicting onset of early recurrence in recently diagnosed hepatocellular carcinoma

Introduction: Early recurrence of hepatocellular carcinoma (HCC) is a major risk factor affecting survival even after hepatectomy. Many clinical, biochemical parameters and pathological grading like fibrosis 1 index have been used for risk stratifying HCC. However not many studies have combined all of them. It is therefore important to risk stratify HCC especially with newer PE...

متن کامل

Imaging neuroendocrine tumours of the pancreas: role of CT and MRI

Pancreatic neuroendocrine tumours (pNETS) are a part of a heterogeneous group of tumors, neuroendocrine gastroenteropancreatic tumors (GEP-NETs), with their origin in neuroendocrine cells of the embryological gut. Most commonly, primary lesions are located in gastric mucosa, small and large intestine, rectum and pancreas. The overall incidence of all GEP-NETS has increased over the past decade,...

متن کامل

F-18 FDG PET/CT imaging of primary hepatic neuroendocrine tumor

Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare neoplasms. Herein, we report a case of a 70-year-old man with a hepatic mass. The non-contrast computed tomography (CT) image showed a low-density mass, and dynamic CT images indicated the enhancement of the mass in the arterial phase and early washout in the late phase. F18- fluorodeoxyglucose (18F-FDG) positron emission tomogra...

متن کامل

I-55: Molecular Imaging Overview

Molecular imaging is the noninvasive visualization of normal as well as abnormal cellular processes at a molecular or genetic level of function. It is used to provide characterization and measurement of biological processes in living animals and humans (in vivo). The discipline of molecular imaging evolved rapidly over the past decade through the integration of cell biology, molecular biology a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2014